Performance diagnóstica da ressonância magnética para detecção de nódulos pulmonares comparado à tomografia computadorizada : revisão sistemática e metanálise

Abstract

Computed tomography (CT) is currently the reference standard for detection of pulmonary nodules. Has as limitations the use of ionizing radiation and limited capacity to provide malignancy stratification of a significant subset of nodules. In this context, magnetic resonance imaging (MRI) could be used as alternative for this detection, as it doesn´t use ionizing radiation and have some sequences able to provide malignancy stratification. Although MRI overcomes these specific limitation of CT, the sensitivity of the method for detection of lung nodules is unclear. The objective of this Systematic Review and Meta-Analysis is to compare the diagnostic performance of MRI for the detection of pulmonary nodules >= 4 mm with the CT as reference standard. PubMed, Embase, and Scopus databases will be systematically searched from January 2000 to March 2023 for relevant published studies evaluating the diagnostic performance of MRI for diagnosis of lung nodules ≥4 mm using CT as reference standard. Studies including micronodules without stratified analysis by size or those from which data for contingency tables could not be extracted were excluded. Primary outcomes will be the per-lesion sensitivity and the false positive rate (FPR) per patient of MRI. Subgroup analysis by size and other variables are also planned.