Hormônio de crescimento na formação óssea ao redor de implantes de titânio – uma revisão sistemática da literatura

Abstract

Objective: The objective of this study was to evaluate the bone formation around dental implants with the use of growth hormone (GH) on its surface. Materials and Methods: The systematic review was conducted from 1993 to 2019. The terms used for the research were "dental implantation", "growth hormone" and "osseointegration" to identify pre-clinical and clinical studies in vivo. A two-stage search strategy was used. Initially, 31 potentially relevant articles were identified. After removing duplicate articles, 12 studies were included. Results: All selected studies were pre-clinical trials in animals, and the follow-up period varied between 1 and 8 weeks. Nine included studies showed increased contact with bone implants in groups that received growth hormone compared to control groups. Conclusion: Growth hormone was able to increase bone formation around titanium implants and may be an alternative for patients with systemic problems.