Avaliação do reparo tecidual em defeitos ósseos críticos preenchidos com biomaterial matriz de PLGA/rhGH e submetidos a terapia com LLLT : estudo em ratos

Abstract

The present study had the objective of reviewing the literature on the use of Growth Hormone in bone regeneration. It was done a search in the PubMed database with the following mesh terms: "Growth hormone", "bone regeneration", "Dentistry", with the Boolean operator "AND". We also consulted the Cochrane database, in which no study was found. We found 33 articles and after reading the titles and abstracts and applying the inclusion and exclusion criteria, 11 studies were selected. These articles were grouped in the following categories: use of GH in osseointegration and use of GH in bone repair. Data were tabulated according to the type of sample, usage form of GH and time of observation. Analyzing the selected articles, it has been observed that the mode of GH use in most studies is topical and doses range from 2UI to 4UI. Most studies have evaluated the effect of GH on Peri-implant bone healing, with only 3 of these articles evaluating this effect in cases of osteogenic distraction, and only one study was performed on critical bone defects by administering GH in a systemic way. Within the limits of this review, it has been observed that GH has been shown to be a good alternative to accelerate bone regeneration.