Revisão sistemática e meta-análise de tomografia por emissão de pósitrons (PET) com antígeno da membrana específica da próstata (PSMA) marcado com 68GA, no câncer de próstata

Abstract

The purpose of this study was to assess the diagnostic performance of 68Ga–Prostate-specific Membrane Antigen (PSMA) Positron Emission Tomography (PET) for detection of prostate cancer and recurrent prostate cancer. Methods: A systematic search was performed in PubMed, Cochrane and Embase to identify relevant published studies reporting on the performance of 68Ga–Prostate-specific Membrane Antigen (PSMA) PET in patients with suspected, confirmed, untreated or recurrent Prostate Cancer. A composite standard included changing in PSA values, clinical follow–up and histopathological findings as reference standard. Results: Thirty-five studies including in total 3532 patients who underwent a 68Ga-PSMA PET met our inclusion criteria. We obtained a pooled positive likelihood ratio (LR) of 1.81 (0.75 to 4.36) with 0% heterogeneity. For patients with PSA <0.5ng/mL, the positive LR pooled estimate was 1.17 (0.37-3.73) and the sensitivity was 56% (0.42-0.68). Conclusion: This meta-analysis of available studies demonstrates that 68Ga-PSMA PET appears to provide good sensitivity and specificity.