Geração de imagens para a quantificação das lesões de esclerose múltipla com exames de ressonância magnética do cérebro humano utilizado no protocolo de rotina da prática clínica

Abstract

The images, which correspond to slices in MRIs are part of the protocols used to aid in the diagnosis of multiple sclerosis and have lesions that characterize the disease. Among existing protocols, are the routine protocol and protocol specific for the disease being evaluated. The MRI scan of the specific protocol is an expensive and time-consuming test, but presents a more accurate quantification of volumetric lesion in the brain. The MRI scan of the routine protocol is an inexpensive routine examination; however, its accuracy is lower for quantifying the volume of multiple sclerosis lesions, due to the fact that it has a lower amount of data. Within this context, this dissertation presents the application of interpolation methods to generate artificial images through the images on the MRI scan of the routine protocol in order to simulate the images of the specific protocol for multiple sclerosis. At the end, an approach is presented that aims to improve the precision obtained with the interpolation techniques used to increase the reliability of volumetric lesion generated by interpolations.