Efeito da terapia cirúrgica anti-infecciosa sobre biomarcadores imunológicos em pacientes portadores de peri-implantite

Abstract

The objective of the present study was to evaluate the effects of an antiinfective surgical therapy over 20 peri-implant crevicular fluid biomarkers in patients with peri-implantitis and to compare these immunologic profiles with the clinical parameters. Fifty-two patients presenting implants affected by peri-implantitis were classified into 4 groups according with probing depth and the presence of bleeding and/or suppuration at mesio-buccal site of each implant with periimplantitis. Clinical parameters were measured and PICF samples were collected from the mesio-buccal site of every implant. All subjects were submitted to anti-infective surgical therapy. Clinical parameters and PICF biomarkers were re-measured at 6 and 12 months after treatment. PICF samples were analyzed using multiplex bead immunoassay for 20 biomarkers. Differences over time were analyzed using generalized estimating equations. The significance level established for all analyses was 5% (p <0.05). The results demonstrated a significant reduction of the clinical parameters post-therapy. However, it was observed a significant increase of some pro-inflammatory biomarkers levels (IL-1β, IL-6, IL-12p40, IL-12p70, IL-17a e sCD-40L). And IL-13 was the only anti-inflammatory cytokine, which had a significant increase in its levels after anti-infective surgical therapy.