@PHDTHESIS{ 2021:1830240798,
 	title = {Development of pet tracers for M2-macrophages},
 	year = {2021},
 	url = "https://tede2.pucrs.br/tede2/handle/tede/10366",
 	abstract = "Several people in the world suffer from Central or Peripheral Nervous System diseases, like Rheumatoid Arthritis, Crohn?s Disease, Alzheimer?s Disease, Parkinson?s Disease, Multiple Sclerosis, and beyond. All these diseases share the same problem: inflammation. Inflammation leads to disease progression and consequently to deeply decrease in individual life quality. The longevity feature is getting more and more present in the world where the understanding and, optimistically, the cure of those diseases in the elderly life are increasing progressively. High inflammation increases cell infiltration in response to cellular damage. Macrophages are one of the most important cells of homeostasis, and they are directly involved in the inflammatory process. The CD163 receptor is an antiinflammatory macrophage surface receptor, which is responsible for hemoglobinhaptoglobin complex clearance since free hemoglobin (Hb) can be extremely toxic to organisms due to free heme. Besides the macrophages fundamental role in the inflammatory process, they also seem to be crucial in the tumoral microenvironment Several tumors (i.e. colon, breast, and bladder cancer) show increase macrophages infiltration, being called as tumor-associated macrophages (TAMs). Among such the environment against diseases that lead to longevity regression (e.g. inflammatory diseases and tumors), the science search to understand them to promote its resolution, providing an increase in people's life quality. Therefore, several imaging methods have been used for screening, diagnosis, and therapy of cell damages in the human body. Amid them, PET (Positron Emission Tomography) imaging is the main method used in Nuclear Medicine. In Nuclear Medicine few radiopharmaceuticals can bind pro-inflammatory and anti-inflammatory receptors; however, there is none specifically for anti-inflammatory receptors (as the CD163 receptor) to be used in clinical. Radioisotopes as 18F and 68Ga are easily found at Nuclear Medicine due to present short half-life (? 110 and 68 minutes, respectively) and their imaging acquisition in only one day (less radiation exposition for the patient), becoming the radioisotopes most used in Brazil. This new radiopharmaceutical may help to understand the mechanisms involved in the inflammatory process; provide a drug screening for new drugs, and personalized treatment for the patient through the individualize therapeutic screening.",
 	publisher = {Pontif?cia Universidade Cat?lica do Rio Grande do Sul},
 	scholl = {Programa de P?s-Gradua??o em Gerontologia Biom?dica},
 	note = {Escola de Medicina}
}