Efeito da laserterapia de baixa potência no reparo tecidual pós exodontia em ratos submetidos a terapia com ácido zoledrônico e dexametasona

Abstract

The objectives of this study were: (a) elucidate whether Low Level Laser Therapy has positive effects in the treatment of bisphosphonate-related osteonecrosis of the jaw, by a systematic review of the literature. A systematic search of the PubMed, EMBASE, and Cochrane Library electronic databases was conducted, with no restrictions on language or year of publication. Search strategies were formulated using keywords and Boolean operators. The electronic search strategy retrieved 55 records. From 55 articles of wich 10 were ultimately included for data analysis in this review. Our findings show that treatment modalities including laser was associated with superior outcomes in terms of cure or improvement of bisphosphonate-related osteonecrosis of the jaw lesions as compared with conventional surgical and/or conservative drug therapy. It can be concluded that combined treatment with antibiotics, minimally invasive surgery (including Er:YAG laser surgery), and Low Level Laser Therapy in the early stages of the disease should be the gold standard for bisphosphonate-related osteonecrosis of the jaw management. (b) evaluate the influence of Low Level Laser Therapy in the 685nm and and 830nm wavelength (emission of red and infrared light repectivamente) in the healing process of the bone and soft tissues in rats under bisphosphonate therapy, zoledronic acid, and dexamethasone concomitantly underwent a surgery for extraction of upper molars. For this study were used twenty-eight Rattus norvegicus Wistar race, randomly divided into 4 groups of 7 animals each, one vehicle control group, a medication control group (administered Zoledronic Acid and dexamethasone) and other 2 groups wich were administered Zoledronic Acid and dexamethasone, one group was treatede with a laser with red light emission and the another onde with the and infrared light emission. There were statistically significant differences in the clinical evaluation of the wound and the weight of the animals. Regarding the histological evaluation, there were no statistically significant differences, although there are differences in the descriptions of the groups because it was possible to observe the difference maturation of the healing stage between groups. The effect of drug therapy with Zoledronic Acid and dexamethasone in the bone tissue repair process, induce osteonecrosis of the jaw in rats and slows down the healing process and we had positive influence on the bone and soft tissue repair process in the laser groups with red and infrared light emission at the stipulated dosimetry.