Efeitos citotóxicos e genotóxicos das ligas de solda de prata em ortodontia : revisão sistemática

Abstract

A systematic review was performed on the cytotoxic and genotoxic effects of silver solder alloys in orthodontics. The search was conducted through medical databases, PubMed, EMBASE, Web of Science and Cochrane Library. The search of gray literature included the annals of the meetings of the Brazilian Society for Dental Research (SBPqO) and of the American Association of Orthodontists (AAO). The articles found were submitted to selection criteria and eligibility by two independent blind researchers. Afterwards, a manual search was conducted on articles’s references and study data were extracted by standardized forms. Sixty-four out of 76 articles were excluded because they did not reach the eligibility criteria. The remaining 12 articles and 3 other raised from manual search were included in this study. Two articles found on gray literature were repeated, though excluded. The level of agreement between researchers was adequate in the selection criteria (kappa = 0.916) and very precise for the eligibility (kappa = 1). As a conclusion of the systematic review, the silver solder alloy may cause cytotoxic, mutagenic and genotoxic effects when applied on orthodontic treatment.